Rangers go in 2-0 down at half time after a double from Simeone in Naples.
Gers defender Ben Davies was handed an early yellow card for a rash tackle after just eight minutes.
And Napoli took the lead just three minutes later through a strike from Simeone.
The same player doubled the Italians’ lead on the 16th minute after intense pressure from the Serie A side.
Can Rangers turn it around in the second half?