Hibernian striker Kevin Nisbet continues his comeback from a knee injury but the visit of St Johnstone in the cinch Premiership comes too soon.
Elias Melkersen has recovered from a knock and will be in contention for a game which sees the use of VAR in Scottish football for the first time.
Lewis Miller and Momodou Bojang will miss out along with Aiden McGeady and Jake Doyle-Hayes.
St Johnstone playmaker Graham Carey could return to action at Easter Road.
Boss Callum Davidson revealed the midfielder, out since early September with a knee injury, has returned to training and is a possibility for the trip to Leith.
Saints are without long-term absentees Murray Davidson, Chris Kane, Callum Booth and Cameron MacPherson.